Engineering blog

How we're building UNMIRI.

Architecture, clinical data pipelines, and HIPAA-ready AI. Written for the engineering teams at healthtech and EHR vendors, the medical affairs leaders at oncology biotechs, and the pathologists who interpret these reports daily.

Industry & compliance··4 min read

Somdutta Saha Joins UNMIRI as Technical and Scientific Advisor

Somdutta Saha, PhD, a translational bioinformatics leader with biopharma NGS and biomarker experience, joins UNMIRI as Technical and Scientific Advisor.

TeamAdvisorsTranslational BioinformaticsNGSSBIR
Clinical data & genomics··8 min read

Real-Time Congress Intelligence for Medical Affairs Teams

Monitor ASCO, ESMO, AACR, ASH, and WCLC abstracts as they post using Crossref DOI metadata. How oncology medical affairs teams track congress evidence without manual triage.

Medical AffairsCongress IntelligenceASCOESMOMSL
Clinical data & genomics··8 min read

Mapping Oncology KOLs From Open Data: A Practical Guide

How to identify and rank oncology key opinion leaders from public data: OpenAlex citations, ORCID and ROR IDs, congress presence, and trial PI activity. For medical affairs and MSL teams.

Medical AffairsKOLOpenAlexORCIDMSL
Industry & compliance··9 min read

Citation-Grounded AI for Medical Information and MSL Use

Why grounding, provenance, and refusal beat ungrounded LLMs for medical information and MSL literature responses. GraphRAG over PubMed and an evidence graph, with every answer cited.

Medical AffairsGraphRAGMedical InformationCitationsMSL
Architecture & engineering··8 min read

Four New APIs on One Data Plane

UNMIRI's Tier 1 and Tier 2 APIs now ship: mCODE-compatible NGS output, variant-grounded trial matching, genomics-aware CDS, and a prior-authorization decision engine, all on one knowledge graph.

ProductAPITrial MatchingPrior AuthorizationCDS
Architecture & engineering··6 min read

Open-Sourcing the UNMIRI NGS Interpretation Schema

UNMIRI is releasing a vendor-agnostic, FHIR-Genomics-aligned API contract for cross-vendor NGS interpretation under Apache 2.0: JSON Schemas, TypeScript types, pydantic models, and 8 synthetic worked examples covering the most common finding patterns.

Open SourceFHIR GenomicsNGSCross-VendorAPI Design
Architecture & engineering··10 min read

Cross-Vendor NGS Report Parsing: Why Foundation, Tempus, Caris, and Guardant Outputs Don't Compose

Why Foundation Medicine, Tempus, Caris, and Guardant NGS report formats don't compose, and what defensible cross-vendor parsing actually requires.

NGS ParsingFHIR GenomicsFoundation MedicineTempusCarisGuardant
Clinical data & genomics··9 min read

BRCA2 in Metastatic Prostate Cancer: How PARP Inhibitor Decision Logic Should Actually Work

How PARP inhibitor decision logic for BRCA2-mutated metastatic prostate cancer requires variant-aware, line-of-therapy-aware reasoning that generic CDS systems struggle with.

BRCA2Prostate CancerPARP InhibitorsClinical Decision SupportVariant-Aware CDS
Architecture & engineering··9 min read

Why Vector RAG Fails for Oncology — and What to Build

How BRAF V600E vs V600K breaks vector RAG, plus the GraphRAG architecture with Neo4j schema and Cypher queries UNMIRI uses in production instead.

GraphRAGNeo4jClinical AIArchitecture
Industry & compliance··10 min read

Building a HIPAA-Ready Architecture for Clinical Decision Support

How UNMIRI minimizes LLM use in the clinical path (GraphRAG plus deterministic templates), plus the BAA chain, data-flow diagram, and vendor-evaluation checklist.

HIPAABAALLM APIsComplianceArchitecture