Engineering blog

How we're building UNMIRI.

Architecture, clinical data pipelines, and HIPAA-ready AI. Written for the engineering teams at healthtech and EHR vendors, the medical affairs leaders at oncology biotechs, and the pathologists who interpret these reports daily.

Architecture & engineering··8 min read

Four New APIs on One Data Plane

UNMIRI's Tier 1 and Tier 2 APIs now ship: mCODE-compatible NGS output, variant-grounded trial matching, genomics-aware CDS, and a prior-authorization decision engine, all on one knowledge graph.

ProductAPITrial MatchingPrior AuthorizationCDS
Architecture & engineering··6 min read

Open-Sourcing the UNMIRI NGS Interpretation Schema

UNMIRI is releasing a vendor-agnostic, FHIR-Genomics-aligned API contract for cross-vendor NGS interpretation under Apache 2.0: JSON Schemas, TypeScript types, pydantic models, and 8 synthetic worked examples covering the most common finding patterns.

Open SourceFHIR GenomicsNGSCross-VendorAPI Design
Architecture & engineering··10 min read

Cross-Vendor NGS Report Parsing: Why Foundation, Tempus, Caris, and Guardant Outputs Don't Compose

Why Foundation Medicine, Tempus, Caris, and Guardant NGS report formats don't compose, and what defensible cross-vendor parsing actually requires.

NGS ParsingFHIR GenomicsFoundation MedicineTempusCarisGuardant
Clinical data & genomics··9 min read

BRCA2 in Metastatic Prostate Cancer: How PARP Inhibitor Decision Logic Should Actually Work

How PARP inhibitor decision logic for BRCA2-mutated metastatic prostate cancer requires variant-aware, line-of-therapy-aware reasoning that generic CDS systems struggle with.

BRCA2Prostate CancerPARP InhibitorsClinical Decision SupportVariant-Aware CDS
Architecture & engineering··9 min read

Why Vector RAG Fails for Oncology — and What to Build

How BRAF V600E vs V600K breaks vector RAG, plus the GraphRAG architecture with Neo4j schema and Cypher queries UNMIRI uses in production instead.

GraphRAGNeo4jClinical AIArchitecture
Industry & compliance··10 min read

Building a HIPAA-Ready Architecture for Clinical Decision Support

How UNMIRI minimizes LLM use in the clinical path (GraphRAG plus deterministic templates), plus the BAA chain, data-flow diagram, and vendor-evaluation checklist.

HIPAABAALLM APIsComplianceArchitecture